Yazar "Özbil, Mehmet" için listeleme
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Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target proteins: A Molecular Docking Study
Çubuk, Hasan; Özbil, Mehmet (TUBITAK, 2021)The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China, numerous drug design studies have been conducted all over the globe. ... -
Computational Analysis of Functional Monomers Used in Molecular Imprinting for Promising Covid-19 Detection
Çubuk, Hasan; Özbil, Mehmet; Hatır Çakır, Pınar (Elsevier, 2021)Today, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently caused a severe outbreak worldwide. There are still several challenges in COVID-19 diagnoses, such as limited reagents, equipment, and long ... -
Computational insight into the phthalocyanine-DNA binding via docking and molecular dynamics simulations
Özalp, Lalehan; Erdem Sağ, Safiye; Yüce Dursun, Başak; Mutlu, Özal; Özbil, Mehmet (Elsevier, 2018-12)Phthalocyanines are considered as good DNA binders, which makes them promising anti-tumor drug leads. The purpose of this study is to investigate the interactions between DNA and quaternary metallophthalocyanine derivatives ... -
Computational investigation of influenza A virus M2 protein inhibition mechanism by ion channel blockers
Özbil, Mehmet (Scientific Technical Research Council Turkey-TUBITAK, 2019)The M2 protein of the influenza A virus, responsible for flu, is a homotetramer transmembrane protein, forming a transmembrane ion channel, where His 37s act as pH sensors and Trp 41s and Asp 44s act as channel gates. ... -
Functional characterisation of the type 1 von Willebrand disease candidate VWF gene variants: p. M771I, p. L881R and p. P1413L
Berber, Ergül; Özbil, Mehmet; Brown, Christine; Başlar, Zafer; Çağlayan, S. Hande; Lillicrap, David (SIMTI Servizi, 2017)Background. Abnormalities in the biosynthetic pathway or increased clearance of plasma von Willebrand factor (VWF) are likely to contribute to decreased plasma VWF levels in inherited type 1 von Willebrand disease (VWD). ... -
HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions
Fareed, Fareed M. A.; Korulu, Şirin; Özbil, Mehmet; Çapan Yalçın, Özlem (Springer, 2021)Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus. Functional characterization of mutant proteins reveals ... -
Mechanisms of peptide hydrolysis by aspartyl and metalloproteases
Paul, Thomas J.; Barman, Arghya; Özbil, Mehmet; Bora, Ram Prasad; Zhang, Tingting; Sharma, Gaurav; Hoffmann, Zachary; Prabhakar, Rajeev (Royal Society of Chemistry, 2016)Peptide hydrolysis has been involved in a wide range of biological, biotechnological, and industrial applications. In this perspective, the mechanisms of three distinct peptide bond cleaving enzymes, beta secretase (BACE1), ... -
Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors
Göktaş, Füsun; Özbil, Mehmet; Cesur, Nesrin; Vanderlinden, Evelien; Naesens, Lieve; Cesur, Zafer (Wiley, 2019)Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the synthesis and structure-activity relationship of some novel ...
