Dual-Drug Delivery of Ag-Chitosan Nanoparticles and Phenytoin Via Core-Shell PVA/PCL Electrospun Nanofibers
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Erişim
info:eu-repo/semantics/closedAccessTarih
2021Yazar
Şahin, Yeşim MügeHüseyin, Mohamed Ahmed Mohamady
Güler, Ece
Rayaman, Erkan
Cam, Muhammet Emin
Şahin, Ali
Grinholc, Mariusz
Mansuroğlu, Demet Sezgin
Gündüz, Oğuzhan
Muhammed, Memun
El-Sherbiny, İbrahim M.
Meghed, Mosaad
Üst veri
Tüm öğe kaydını gösterKünye
Hussein, M. A. M., Guler, E., Rayaman, E., Cam, M. E., Sahin, A., Grinholc, M., ... & Megahed, M. (2021). Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers. Carbohydrate Polymers, 270, 118373.Özet
Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.