Exploring the composition and potential uses of four hops varieties through different extraction techniques
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info:eu-repo/semantics/closedAccessTarih
2024Yazar
Kljakic, Aleksandra CvetanovicOcvirk, Miha
Rutnik, Ksenija
Kosir, Iztok Joze
Pavlic, Branimir
Maskovic, Pavle
Maskovic, Jelena
Teslic, Nemanja
Stupar, Alena
Uba, Abdullahi Ibrahim
Zengin, Gokhan
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Kljakić, A. C., Ocvirk, M., Rutnik, K., Košir, I. J., Pavlić, B., Mašković, P., ... & Zengin, G. (2024). Exploring the composition and potential uses of four hops varieties through different extraction techniques. Food Chemistry, 138910.Özet
Hydrophilic, lipophilic extracts and essential oil of four hops varieties from Slovenia were examined in this study. Lipophilic extracts were obtained by supercritical extraction (SFE), while for hydrophilic extracts ultrasound and microwave extraction were employed. Essential oils were isolated by the hydrodistillation process. The lipophilic composition of essential oils and lipophilic extracts was determined by GC-MS analysis. Monoterpenes and sesquiterpene hydrocarbons were the most abundant class of compounds in oils (62.27-79.65 %), with myrcene being the most abundant constituent. Limonene and trans-caryophyllene were two terpenes determined in all essential oils while only trans-caryophyllene was detected in SFE samples. Antioxidant, antimicrobial, and cytotoxic activity, determined by applying in vitro assays, was more influenced by extraction technique than by varieties. Molecular docking was carried out to gain insight into the potential cancer protein targets BCL-2 and MMP9, whereby humulene epoxide II displayed good binding configuration within the cavities of the two proteins.