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dc.contributor.authorDall'Acqua, Stefano
dc.contributor.authorYagi, Sakina
dc.contributor.authorSut, Stefania
dc.contributor.authorUba, Abdullahi Ibrahim
dc.contributor.authorYildiztugay, Evren
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorYuksekdag, Ozgur
dc.contributor.authorPonniya, Sathish Kumar M.
dc.contributor.authorJayavel, Ashokkumar
dc.contributor.authorZengin, Gokhan
dc.date.accessioned2024-07-22T07:15:11Z
dc.date.available2024-07-22T07:15:11Z
dc.date.issued2024en_US
dc.identifier.citationDall’Acqua, S., Yagi, S., Sut, S., Uba, A. I., Yildiztugay, E., Koyuncu, I., ... & Zengin, G. (2024). Unlocking the functional potential of Nitraria schoberi extracts using chemical fingerprinting, biological efficiencies, in silico and network pharmacological approaches. Food Bioscience, 60, 104278.en_US
dc.identifier.issn22124292
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2024.104278
dc.identifier.urihttps://hdl.handle.net/20.500.12294/4134
dc.description.abstractTanacetum nitens ( Boiss. & No & euml;) Grierson is an aromatic perennial herb used in Turkish traditional medicine to treat headache, fever, and skin diseases. This study aimed to investigate the chemical composition, antioxidant, enzyme inhibition, and cytotoxic properties of T. nitens aerial parts. Organic solvent extracts were prepared by sequential maceration in hexane, dichloromethane, ethyl acetate, and methanol while aqueous extracts were obtained by maceration or infusion. Nuclear magnetic resonance (NMR) and LC-DAD-MS analysis allowed the identification and quantification of different phytoconstituents including parthenolide, tanacetol B, tatridin B, quinic acid derivatives, beta-sitosterol, and glycoside derivatives of quercetin and luteolin. The type and amount of these phytochemicals recovered by each solvent were variable and significant enough to impact the biological activities of the plant. Methanolic and aqueous extracts displayed the highest scavenging and ions-reducing properties while the dichloromethane and ethyl acetate extracts exerted the best total antioxidant activity and metal chelating power. Results of enzyme inhibition activity showed that the hexane, ethyl acetate, and dichloromethane extracts had comparable anti-acetylcholinesterase activity and the latter extract revealed the highest anti-butyrylcholinesterase activity. The best alpha-amylase and alpha-glucosidase inhibition activities were obtained from the hexane extract. The dichloromethane and ethyl acetate extracts exhibited the highest cytotoxic effect against the prostate carcinoma DU-145 cells. In conclusion, these findings indicated that T. nitens can be a promising source of biomolecules with potential therapeutic applications.en_US
dc.language.isoengen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofARCHIV DER PHARMAZIEen_US
dc.identifier.doi10.1016/j.fbio.2024.104278en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIN-VITROen_US
dc.subjectANTIOXIDANTen_US
dc.subjectACETYLCHOLINESTERASEen_US
dc.subjectENZYMEen_US
dc.subjectL.en_US
dc.subjectPARTHENOLIDEen_US
dc.subjectPERFORMANCEen_US
dc.subjectINHIBITIONen_US
dc.subjectGLYCOSIDESen_US
dc.subjectFLAVONOLen_US
dc.titleCombining chemical profiles and biological abilities of different extracts from Tanacetum nitens ( Boiss. & NoE) Grierson using network pharmacologyen_US
dc.typearticleen_US
dc.departmentFen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.authorid0000-0002-0853-108Xen_US
dc.identifier.volume60en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.institutionauthorUba, Abdullahi Ibrahim
dc.authorwosidP-3971-2019en_US
dc.authorscopusid57038704300en_US
dc.identifier.wosqualityQ1en_US
dc.identifier.wosWOS:001250133500001en_US
dc.identifier.scopus2-s2.0-85192311178en_US


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